The funds shall come in for five years. The WEHI was also granted a $17.1 million system to further studies of the molecular procedures that regulate blood cell production and function. We found that cell death is frequently blocked in cancer cells, so we are now attempting to develop medicines that flip the natural cell death switch back on. Other research projects on the cards for financing are the $15.7 million to the Australian Nationwide University project to explore autoimmune diseases, inflammation, immunodeficiency and allergy.Mutations in genes encoding the different parts of the splicing machinery had been found in 9 patients , and mutations in the gene encoding the thrombopoietin receptor were recognized in 7 patients, all of whom had essential myelofibrosis or thrombocythemia with unmutated JAK2. Mutations in genes that are reported to be mutated in myeloproliferative neoplasms at low frequencies were found in 4 individuals . Missense somatic mutations in CHEK2, which have not really been reported in myeloproliferative neoplasms previously, were found in 1 individual each with polycythemia vera, important thrombocythemia, and myelofibrosis . We also assessed pairwise associations between genes mutated in myeloproliferative neoplasms .28 Recurrent Somatic CALR Mutations A impressive pattern of somatic mutations was observed in CALR, a gene that hadn’t previously been named an oncogene mutated in any form of cancer.