Coauthors and Mathew. A framework is supplied by The review for this complex disease that will require a diverse approach in research, treatment and diagnosis. Current treatment plans are limited by their delayed starting point of action, lack of efficacy and adverse outcomes. The authors conclude that ‘much must be explored with regards to how genes interact with various other environmental variables to impact the risk of main depressive disorder.’..Americanum is not thought to expand into Wisconsin and Minnesota, and open public submissions of A. On the other hand, both D. Variabilis and I. Scapularis are abundant, human-biting species in northwestern Minnesota and Wisconsin. The current presence of ehrlichia species Wisconsin DNA in at least 17 I. Scapularis adults and nymphs, as well as the absence of ehrlichia DNA in the D. Variabilis ticks examined, shows that I. Scapularis is definitely a vector for ehrlichia species Wisconsin. Prolonged investigation and tick surveillance are required to understand the distribution of the agent in Wisconsin and Minnesota also to definitively implicate a specific tick vector.