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Cohort 3 will enroll sufferers whose tumor expresses high levels of the NY-ESO-1 antigen and will study the removal of fludarabine within the lymphodepletion regimen. Both cohorts concurrently are expected to open.. Adaptimmune doses first individual in expanded Phase We/II trial of T-cell therapy for synovial sarcoma Adaptimmune Therapeutics plc , , a clinical stage biopharmaceutical company focused on the use of T-cell therapy to treat malignancy, today announced that the initial patient has been dosed in its expanded Stage We/II trial of its affinity enhanced T-cell receptor therapeutic targeting the NY-ESO-1 cancer antigen in synovial sarcoma individuals. Based on encouraging results in the 1st cohort of 10 sufferers, presented at the American Association for Cancer Research annual conference in April 2015, the trial has been expanded to encompass an additional 20 patients in two further cohorts.