Therefore, the AAP appreciates the chance to provide this testimony to the CDC greatly. We anticipate continued collaboration with the CDC Division of TEETH’S HEALTH to measure the prevalence of periodontal disease, and optimistically, to increase public knowing of the importance of healthy gums and teeth. .. AAP testimony asks CDC DOH to add periodontal surveillance as part of strategic priorities The American Academy of Periodontology was recently invited to supply testimony to the Centers for Disease Control and Prevention’s Division of TEETH’S HEALTH within the strategic planning process for 2011 through 2014.At the time of disease progression, when the individual was taking crizotinib, a replicate biopsy was performed to recognize the mechanism of drug resistance. The biopsy was performed relative to a clinical protocol that was approved by the institutional review table at our institution designed for patients in whom resistance has developed to targeted therapies such as for example crizotinib and erlotinib. Do it again biopsies possess emerged as an invaluable tool for discovering clinically relevant level of resistance mechanisms, including secondary mutations within the mark, activation of substitute signaling pathways, and in the case of EGFR-mutant lung cancer, small-cell transformation.23 Elucidating these mechanisms has helped to guide the advancement of new treatment strategies made to overcome resistance.